CJC1295 with DAC
CJC-1295 is a long acting growth hormone releasing hormone (GHRH) analog. GHRH, also known as growth hormone releasing factor or somatocrinin, is 44-amino acid peptide hormone which is produced by the arcuate nucleus in the hypothalamus. It stimulates secretion of growth hormone from the pituitary gland and is released in a pulsatile manner to ultimately stimulate pulsatile release of growth hormone. This pulsatile release in various peptides is the root cause for half life of the peptide due to an enzyme called dipeptidylaminopeptidase IV (DPP-IV). Thus the need for increasing the life and bioavailability of peptide compelled pharmaceutical companies to come up with technologies like PEGylation to make peptides even more effective.
Thus CJC-1295 which is a synthetic modification of GHRH with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 27 respectively, is applied with Drug Affinity Complex (DAC) technology to its GHRH to increase its half-life. CJC-1295 DAC peptide carefully and covalently combines to circulate albumin after subcutaneous (SC) administration leading to lengthen its half life from seven minutes to more than seven days. With the help of highly effective bioconjugation process, hardly I % of CJC-1295 remain unreacted in vivo and CJC-1295 molecule attach itself to albumin easily for prolong half-life. There are several benefits that can be assured with CJC-1295 DAC after conducting its effective test on mice in clinical lab.
Its main function is to increase protein synthesis and stimulate new muscle tissue growth. It effectively curbs growth hormone (GH) deficiency in children to let them grow normally. CJC-1295 DAC leads to an increase in muscle mass and also adds to physical strength. It is also helpful in controlling skin aging and effective in reducing wrinkles. CJC-1295 DAC leads to re-growth of internal organs atrophied with age and result in hyperplasia to increase the number of muscle cells. Besides there are other benefits like increased bone density, strong immunity, faster recovery from injuries and lipolysis promotion to reduce body fat. As per dose recommendation, it is tested that a dose of 30 or 60 µg/kg is ideal to increase GH and insulin like growth factor (IGF-1) in healthy adults. Also due to long half-life and stability, taking CJC-1295 DAC 1-2 times per week would do the required job
An reduction of body fat – CJC 1295 with DAC’s mechanics have shown an ability to promote lipoysis, also known as the process in which lipids can get broken down. This process of lipid degradation allows for the levels of adipose tissue (that is, body fat) to lessen.